Endocrine Abstracts

There are a number of endocrine changes which occur during the aging process, including changes in the growth hormone – IGF1 axis, a fall in DHEAS levels, changes in the renin-angiotensin system, and alterations in the hypothalamo-pituitary gonadal axis. Testosterone levels decline with age, with an average decrease in testosterone levels of approximately 1.5% per year. The prevalence of subphysiological testosterone levels is approximately 20% by the age of 50 and 50% by...

A 19 year old Caucasian male presented with nausea and malaise. In the past medical history he had been obese since childhood with hyperphagia and abnormal food seeking behaviour. His father was obese and had type I diabetes mellitus. His mother was also obese and had impaired glucose tolerance.On examination he was morbidly obese (body mass index 46.9 Kg/M2) and had axillary acanthosis nigracans. He had clinical features of hypovolaemic shock...

BackgroundThe role of endocrine testing in idiopathic gynecomastia is controversial. Previous studies suggested that such testing is rarely productive and best done selectively.ObjectivesA retrospective study was performed to evaluate the usefulness of a routine endocrine testing in patients presenting with gynecomastia.MethodsThe medical records of 71 patients wi...

Brown tumours (osteitis fibrosa cystica) are the classic bone disease of hyperparathyroidism. Parathyroid carcinoma is an uncommon cause of PTH dependent hypercalcaemia. We present the case of a 63-year-old man who presented to the ENT department with persistent right-sided nasal obstruction and nasal swelling. He was otherwise asymptomatic. He had a long history of nasal polyps, which had recently been resected. Brown’s tumour of the maxilla was demonstrated on nasal bio...

Thyroid cancer is rarely seen in the hyperthyroid patient.We present the case of a 59 year-old lady who presented with marked weight loss of more than 30 kg in less than 6 months, lethargy, palpitations and sweats. Clinically she was obese and thyrotoxic with sweaty palms and a tachycardia. No goitre or neck masses were detected. Thyroid function tests confirmed thyrotoxicosis with free T4 89.1 pmol/l (Normal range 9.8–23.1), free T3 20.2 pmol/l (No...

5 α-reductase deficiency is a rare autosomal recessive condition of male psuedohermaphroditism, resulting from mutations of the type 2 isoenzyme 5 α-reductase, crucial in conversion of testosterone to dihydrotestosteroneCase report: Baby P is a full term baby, a product of a consanguineous marriage. The baby had ambigous genitalia with a clitoris, minimal glans tissue at the apex of the labial folds, gonads in the labioscrotal folds and a ureth...

Both thyroid dysfunction and psychological morbidity are common in the general population. Association between mood disorders and overt thyroid dysfunction are well established. Hypothyroid patients are more prone to depression and anxiety is a frequently reported symptom in thyrotoxicosis. However, the relationship between thyroid hormones in the normal range and psychological well being has not been established.In this study we analysed the relationshi...

Numerous number of studies indicate significant role of oxidative stress in the pathogenesis of thyrotoxicosis. The aim of this work was to estimate oxidative metabolism changes in myocardium and effectiveness of olygocrine in the experimental model of thyrotoxicosis.Methods: Thyrotoxicosis was induced in mature white wistar rats by daily administration of L-thyroxine (100 μg/100 g). We have conducted 3 series of experiments studying: (1) effects of...

Objectives: To analyse the outcome of 100 consecutive patients treated for thyrotoxicosis by total thyroidectomy, and compare the efficacy of this treatment modality to I131 therapy and thionamide therapy.Design: Data collected prospectively from a tertiary referral multidisciplinary thyroid clinic on 100 consecutive patients operated on for thyrotoxicosis by one thyroid surgeon. Patient demographics, reasons for selection of surgical treatmen...

Introduction: The biochemical diagnosis of hypophosphataemic rickets relies on measurement of tubular phosphate reabsorption. However, as the renal tubules are immature at birth and the reference range for urine phosphate excretion is not well defined in young children, there is uncertainty about how early in life a biochemical diagnosis of phosphate wasting can be made. In addition, the benefit of early treatment of hypophosphataemic rickets is unclear.<p class="ab...